Because of small size, nanoemulsions are transparent. The term ‘nanoemulsion’ also refers to a miniemulsion which is fine oil/water or water/oil dispersion stabilized by an interfacial film of surfactant molecule having droplet size range 20–600 nm. The emulsifying agent is also known as intermediate or interphase. The dispersed phase is also known as internal phase or the discontinuous phase while the outer phase is called dispersion medium, external phase or continuous phase. It is a thermodynamically unstable system, which can be stabilized by the presence of an emulsifying agent (emulgent or emulsifier). An emulsion is a biphasic system in which one phase is intimately dispersed in the other phase in the form of minute droplets ranging in diameter from 0.1 to 100 μm. Major application includes treatment of infection of the reticuloendothelial system (RES), enzyme replacement therapy in the liver, treatment of cancer, and vaccination. As a drug delivery system they enhance the therapeutic efficacy of the drug and minimize adverse effect and toxic reactions. Magnetic nanoparticles can be used to enhance site specificity. These carriers are solid spheres and their surface is amorphous and lipophilic with a negative charge. Nanoemulsions are a colloidal particulate system in the submicron size range acting as carriers of drug molecules.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |